Disabled with reboot, edit /etc/selinux/config and save..
# vi /etc/selinux/config

# This file controls the state of SELinux on the system.
# SELINUX= can take one of these three values:
# enforcing - SELinux security policy is enforced.
# permissive - SELinux prints warnings instead of enforcing.
# disabled - No SELinux policy is loaded.
SELINUX=enforcing
# SELINUXTYPE= can take one of these two values:
# targeted - Targeted processes are protected,
# mls - Multi Level Security protection.
SELINUXTYPE=targeted

Change to:

# This file controls the state of SELinux on the system.
# SELINUX= can take one of these three values:
# enforcing - SELinux security policy is enforced.
# permissive - SELinux prints warnings instead of enforcing.
# disabled - No SELinux policy is loaded.
SELINUX=disabled
# SELINUXTYPE= can take one of these two values:
# targeted - Targeted processes are protected,
# mls - Multi Level Security protection.
SELINUXTYPE=targeted

 
-Reboot Machine
# reboot

 
Disabled selinux without reboot:
# setenforce 0

Reference: http://linuxmoz.com/centos-disable-selinux/